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1956年,两性霉素B(AmB)的应用,开始了全身性真菌病治疗的新阶段.时至今日,AmB仍然是主要的抗真菌药物.然而,AmB的毒、副作用,特别是严重的肾中毒限制着它的应用.本文综述了AmB肾中毒、发生机理及其预防.
The use of amphotericin B (AmB) started a new phase of systemic mycosis therapy in 1956. AmB remains the major antifungal drug to date, however the toxic side effects of AmB, especially the severe kidney Poisoning limits its application.This paper reviews the mechanism of AmB nephrotoxicity and its prevention.