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目的观察实验性变态反应性脑脊髓炎(EAE)大鼠脊髓中星形胶质细胞的变化,探讨EAE大鼠的发病相关生物学机制。方法采用免疫组化法,对豚鼠全脊髓匀浆诱导的Wistar大鼠EAE的过程中,脊髓内星形胶质细胞变化情况进行研究。结果EAE大鼠症状高峰期时星形胶质细胞开始激活,恢复期时激活达到高峰,而且活化的星形胶质细胞未见表达主要组织相容性抗原(MHC)。结论活化的星形胶质细胞可能与EAE大鼠的恢复有关。
Objective To observe the changes of astrocytes in the spinal cord of rats with experimental allergic encephalomyelitis (EAE) and to explore the related biological mechanisms of EAE. Methods The changes of astrocytes in the spinal cord during EAE induced by whole spinal cord homogenate in guinea pigs were studied by immunohistochemistry. Results Astrocytes began to activate during the peak of symptoms in EAE rats and peaked during recovery, and no major histocompatibility antigen (MHC) was expressed in activated astrocytes. Conclusion Activated astrocytes may be involved in the recovery of EAE rats.