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目的:了解金黄色葡萄球菌烫伤样皮肤综合征患儿的病原菌检出情况及其药敏试验结果,为该疾病的临床治疗提供分析数据。方法:2010年1月~2015年6月我院收治的金黄色葡萄球菌烫伤样皮肤综合征患儿374例作为研究对象。采集患儿的创面分泌物和血液标本进行细菌培养和药敏试验。结果:创面分泌物标本中检出223株病原菌;血培养阳性17例,阳性率4.55%。共检出金黄色葡萄球菌187株,其中耐甲氧西林金黄色葡萄球菌(MRSA)64株,检出率34.22%。甲氧西林敏感金黄色葡萄球菌(MSSA)和MRSA对万古霉素、替加环素、替考拉宁、利奈唑胺的敏感率均为100.00%;MRSA对青霉素、苯唑西林、哌拉西林、头孢哌酮、头孢唑林、头孢呋辛、头孢西丁、阿奇霉素、克林霉素的敏感率均为0。结论:金黄色葡萄球菌烫伤样皮肤综合征的病原学检查尤为重要,应根据药敏试验结果合理使用抗菌药物。
Objective: To understand the detection of pathogenic bacteria in children with Staphylococcus aureus scalded skin syndrome and its drug sensitivity test results, to provide the clinical data for the treatment of the disease. Methods: From January 2010 to June 2015, 374 cases of Staphylococcus aureus scalded skin syndrome admitted to our hospital were studied. Collect wounds and blood samples of children for bacterial culture and drug susceptibility testing. Results: A total of 223 pathogenic bacteria were detected in the specimens of wound exudates; 17 were positive for blood culture, the positive rate was 4.55%. A total of 187 Staphylococcus aureus strains were detected, including 64 methicillin-resistant Staphylococcus aureus (MRSA) strains with a detection rate of 34.22%. The susceptibilities of methicillin-sensitive Staphylococcus aureus (MSSA) and MRSA to vancomycin, tigecycline, teicoplanin and linezolid were all 100.00%. The sensitivity of MRSA to penicillin, oxacillin and piperacillin , Cefoperazone, cefazolin, cefuroxime, cefoxitin, azithromycin, clindamycin sensitivity were 0. Conclusion: The etiological examination of Staphylococcus aureus scalded skin syndrome is particularly important. Antimicrobial agents should be used reasonably based on the results of susceptibility testing.