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目的:探讨氟伐他汀辅助治疗对慢性心力衰竭患者血浆结缔组织生长因子(CTGF)及血浆脑钠肽(BNP)的影响。方法:112例慢性心力衰竭患者随机分为两组,对照组56例给予常规治疗,观察组56例在对照组基础上加用氟伐他汀钠缓释片80 mg,qd。两组均治疗6个月。比较两组临床疗效和治疗前后的CTGF、BNP、血脂水平与心功能指标变化。结果:观察组的临床总有效率明显高于对照组(P<0.05)。治疗前各指标比较差异无统计学意义(P>0.05),治疗后,观察组左室射血分数、左室内径缩短率及高密度脂蛋白均较前升高,且高于对照组;左室舒张末内径、左室收缩末内径,总胆固醇、三酰甘油、低密度脂蛋白,以及血清CTGF、BNP水平较前降低,且低于对照组,差异均有统计学意义(P<0.001)。两组不良反应发生率差异无统计学意义(P>0.05)。结论:常规治疗基础上应用氟伐他汀治疗慢性心力衰竭疗效显著,且能明显改善患者降低患者的血浆CTGF、BNP水平。
Objective: To investigate the effect of fluvastatin adjuvant therapy on plasma connective tissue growth factor (CTGF) and plasma brain natriuretic peptide (BNP) in patients with chronic heart failure. Methods: One hundred and twelve patients with chronic heart failure were randomly divided into two groups. 56 cases in the control group were treated routinely. 56 cases in the observation group were given fluvastatin sodium sustained-release tablets 80 mg qd on the basis of the control group. Both groups were treated for 6 months. The clinical efficacy and the changes of CTGF, BNP, blood lipid and cardiac function before and after treatment were compared between the two groups. Results: The total effective rate in observation group was significantly higher than that in control group (P <0.05). Before treatment, there was no significant difference between each index (P> 0.05). After treatment, left ventricular ejection fraction, shortening of left ventricular diameter and high density lipoprotein in the observation group were higher than those in the control group before treatment The values of end-diastolic diameter, left ventricular end-systolic diameter, total cholesterol, triglyceride, low density lipoprotein and serum CTGF and BNP levels were significantly lower than those of the control group (P <0.001) . There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). CONCLUSION: Fluvastatin is effective in treating chronic heart failure based on routine treatment, and can significantly improve the patients’ plasma CTGF and BNP levels.