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采用麻醉大鼠心肌缺血模型，观察冠脑益嗪对血液流变学的影响。结果表明，阻断冠脉血流３０ｍｉｎ时，血液流变学各参数发生异常变化，于结扎前３ｍｉｎ静脉注射冠脑益嗪５ｍｇ·ｋｇ－１，能明显降低高、中、低切变率下全血粘度，红细胞压积，降低血浆粘度和纤维蛋白原，缩短红细胞电泳时间。提示，冠脑益嗪具有防止结扎冠脉所致的血液流变学各参数变化，改善微循环的作用，可能与降低红细胞压积，提高红细胞变形能力，缩短红细胞电泳时间，抑制红细胞聚集性，降低纤维蛋白原以及影响钙离子等作用有关。
Anesthetic rat myocardial ischemia model was used to observe the effect of coronary capitis on hemorheology. The results showed that when the coronary blood flow was occluded for 30 minutes, the parameters of hemorheology changed abnormally, and coronary angiraculin 5 mg · kg-1 was injected intravenously 3 minutes before ligation, which could significantly reduce the high, middle and low shear rates Whole blood viscosity, hematocrit, lower plasma viscosity and fibrinogen, shorten the time of erythrocyte electrophoresis. These results suggest that coronary aneurysm has the effect of preventing changes of hemorheology parameters and improving microcirculation caused by ligation of coronary artery, which may be related to the reduction of hematocrit, improvement of erythrocyte deformability, shortening of erythrocyte electrophoresis time, inhibition of erythrocyte aggregation, Reduce fibrinogen and affect the role of calcium ions.