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目的:研究溴隐亭不同给药方案在治疗高泌乳素血症(HPRL)女性不育症中的临床疗效,关注其对女性促性腺激素诱导排卵的影响。方法:本研究共纳入60例就诊于我院的确诊为高泌乳素血症不孕不育患者,随机分为两组。分为研究组与对照组:研究组采取先口服溴隐亭调整血清泌乳素水平至正常后予以促性腺激素诱导排卵;对照组采取促性腺激素与溴隐亭同步治疗方案。结果:观察两组患者的促排卵周期数、平均用药天数、雌二醇水平及妊娠率,两组治疗前后的血清泌乳素都显著改善(P<0.05);但是两组之间相比,采取溴隐亭药物治疗后诱导排卵的研究组在促排卵、雌二醇水平和妊娠率方面具有显著优势(P<0.05)。结论:采用溴隐亭治疗高泌乳素血症患者,调整至正常后再使用促卵泡激素药物促排卵治疗不孕不育具为较优的治疗方案。
OBJECTIVE: To study the clinical efficacy of different dosage regimens of bromocriptine in the treatment of female infertility with hyperprolactinemia (HPRL), and to investigate its effect on female ovulation induced by gonadotropin. Methods: A total of 60 patients diagnosed as hyperprolactinemia in our hospital were randomly divided into two groups. Divided into the study group and the control group: the study group took the first oral bromocriptine to adjust serum prolactin levels to normal after gonadotropin-induced ovulation; control group to take gonadotropin and bromocriptine synchronized treatment program. Results: The number of ovulation cycles, average days of treatment, estradiol level and pregnancy rate were observed in both groups. Serum prolactin levels were significantly improved in both groups before and after treatment (P <0.05). However, compared with the two groups, The study group induced ovulation after bromocriptine treatment showed significant advantages in ovulation induction, estradiol level and pregnancy rate (P <0.05). Conclusion: Bromocriptine treatment of hyperprolactinemia patients, adjusted to normal and then use follicle stimulating hormone drugs to promote ovulation treatment of infertility as a better treatment.