作为一类重要的非病毒基因载体,钙类纳米粒子如磷酸钙、碳酸钙等因具有理想的生物相容性和生物降解性而备受关注.本文根据近年来钙类纳米粒子基因传递体系的研究进展,着重评述了通过钙类纳米粒子基因传递体系形貌和结构优化、组分调控及其功能化等来提高基因传递效率方面的研究工作. As a kind of important non-viral gene carrier, calcium nanoparticles such as calcium phosphate, calcium carbonate have drawn much attention because of their ideal biocompatibility and biodegradability.In this paper, based on the gene delivery system of calcium nanoparticles in recent years The progress of the research is focused on the research work on improving the efficiency of gene delivery through the topography and structure optimization of calcium-based nanoparticle gene delivery system, component regulation and its function.