钙离子三磷酸腺苷酶(Ca-ATP酶或Ca泵)是一种整合膜蛋白,它能将水解ATP和跨膜转运钙离子结合起来,调节细胞内钙离子水平。钙离子在细胞信号转导中作为第二信使发挥着关键性作用。根据Ca-ATP酶一级结构、动力学特点和在细胞内定位可将其分为3个亚类。第一类位于质膜上,称为PMCAs;第二类位于肌浆网/内质网上,称为 Calcium Adenosine triphosphatase (Ca-ATPase or Ca pump) is an integral membrane protein that combines the hydrolysis of ATP with transmembrane transport of calcium ions to regulate intracellular calcium levels. Calcium ions play a key role as second messengers in cell signaling. According to the Ca-ATPase primary structure, kinetic characteristics and localization in the cell can be divided into three sub-categories. The first is located on the plasma membrane, called PMCAs; the second is located on the sarcoplasmic / endoplasmic reticulum called