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目的研究气溶胶颗粒在人体上呼吸道模型内的沉积规律,探索有毒气溶胶在人体上呼吸道的致病机理。方法采用ABS材料制作人体上呼吸道实验模型,搭建人体上呼吸道内气溶胶颗粒沉积的实验台,开展不同呼吸流量(30、60 L/min)条件下不同粒径(0.3、6.5μm)的气溶胶颗粒在人体上呼吸道模型中的沉积实验。结果不同呼吸流量下不同粒径气溶胶颗粒在人体上呼吸道模型内沉积模式趋势一致,在咽部、喉部和气管部位沉积较多,且喉部沉积最多。结论呼吸流量对模型内气溶胶颗粒沉积率影响较大,大粒径气溶胶更易沉积到模型中,惯性碰撞和湍流强度是气溶胶颗粒沉积的主要机制。
Objective To study the deposition of aerosol particles in human upper respiratory tract model and to explore the pathogenic mechanism of toxic aerosol in human upper respiratory tract. Methods The experimental model of human upper respiratory tract was made by using ABS material. The experimental platform of aerosol particles deposition in upper respiratory tract of human body was built. Aerosol with different particle sizes (0.3 and 6.5 μm) under different respiratory flow rate (30 and 60 L / min) Deposition of particles in human upper respiratory tract model. Results The aerosol particles with different particle sizes at different respiration fluxes tended to have the same pattern of deposition in the upper respiratory tract of human body. There were more depositions in pharynx, larynx and trachea with the most laryngeal deposits. Conclusions Respiration flow has a great influence on aerosol particle deposition rate in the model. Large particle aerosol is more likely to deposit in the model. The main mechanism of aerosol particle deposition is inertial collision and turbulence intensity.