近日,nature medicine上的一项研究称,乙酰化的tau蛋白是该蛋白的一种毒性形式,能够促进神经退行性损伤和认知缺陷的发生。Salsalate能够成功逆转FTD小鼠模型的疾病表型,降低脑中tau蛋白水平,挽回记忆损伤,并帮助小鼠避免下丘脑萎缩的发生。(源自:药品资讯网) In a recent study in nature medicine, acetylated tau protein is a toxic form of the protein that promotes neurodegeneration and cognitive deficits. Salsalate successfully reversed the disease phenotype of the FTD mouse model, decreased tau protein levels in the brain, restored memory impairment, and helped prevent hypothalamic atrophy in mice. (From: Drug Information Network)