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过氧化物酶增殖物激活受体γ(PPAR-γ)是一种属于核激素受体超家族的核转录因子,可以在包括脂肪、肝脏、肾脏以及肿瘤等多种组织中表达,能够发挥多种生物学作用。文章就PPAR-γ在其激动剂作用下通过负性调控促炎基因包括巨噬细胞的分化和激活来影响炎症因子的表达发挥抑制炎症,对发生缺血再灌注损伤的组织器官以保护进行论述,为进一步的研究缺血再灌注损伤和治疗途径提供了新的方向。
Peroxisome Proliferator Activated Receptor γ (PPAR-γ), a nuclear transcription factor belonging to the nuclear hormone receptor superfamily, can be expressed in many tissues including fat, liver, kidney and tumor and can exert more Biological effects. In this paper, PPAR-γinhibit inflammation by negatively regulating the differentiation and activation of proinflammatory genes, including macrophages, under the action of its agonists, to suppress the inflammation, and discuss the protection of tissues and organs with ischemia-reperfusion injury , Providing a new direction for the further study of ischemia-reperfusion injury and treatment.