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肾素-血管紧张素系统在保持人体钠、血浆容量及血压方面有重要作用。一些研究发现婴儿及儿童血浆肾素活性(PRA)很高,但对发育中胎儿体内肾素-血管紧张素系统的作用却知之甚少,本研究目的是观察正常胎儿的PRA并与病理状态下胎儿的PRA进行比较。对42名胎儿经脐带或经肝静脉穿刺取血,妊娠时间为17～36周,其中20例穿刺取血为产前诊断,分娩结果表明胎儿正常,无IUGR、胎儿水肿、贫血、缺氧及羊水量异常,因此列为正常对照。病理胎儿为5例胎儿水肿(非免疫性)、3例IUGR、2例单侧胸腔积液,5例泌尿系异常(3例下尿道梗阻、1例双侧多囊肾、1例单侧多囊肾)。另外7例为Rh血型不合胎儿。
The renin-angiotensin system plays an important role in maintaining sodium, plasma volume and blood pressure in humans. Some studies have found high plasma renin activity (PRA) in infants and children, but little is known about the role of the renin-angiotensin system in developing fetuses. The aim of this study was to observe the PRA of normal fetuses and compare them with pathological conditions Fetal PRA were compared. Forty-two fetuses were taken blood via umbilical cord or hepatic vein puncture. The pregnancy time ranged from 17 to 36 weeks. Among them, 20 cases were diagnosed as prenatal bleeding by puncturing. The results of delivery showed that the fetus was normal, without IUGR, fetal edema, anemia, hypoxia, Abnormal amniotic fluid, so as a normal control. Pathological fetuses were 5 cases of fetal edema (non-immune), 3 cases of IUGR, 2 cases of unilateral pleural effusion, 5 cases of urinary tract abnormalities (3 cases of lower urinary tract obstruction, 1 case of bilateral polycystic kidney disease, 1 case of unilateral more Cystic kidney). The other 7 cases were Rh blood group with unmarried fetus.