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目的 研究多发性硬化 ( MS)患者听神经脱髓鞘损害。方法 对 2 1例 MS患者 2 3例次脑干诱发电位 ( BAEP) 波异常进行分析 ,以及结合 MRI表现探讨听神经脱髓鞘损害部位。结果 BAEP 波异常单侧 1 7例 ,双侧 4例 ,包括 波两耳潜伏期差 ( ILD)异常 1 1例 , 波消失单、双侧各 2例 ,分化不清 ,潜伏期不肯定 3例 ,潜伏期延长 3例。其中单侧主观听力障碍 2例。同时 ,BAEP显示脑干内损害 1 0例。MRI显示脑干内病灶 5例。结论 部分 MS患者存在听神经远端脱髓鞘损害。主要表现为 I波 IL D异常 ,部分为 BAEP 波潜伏期延长 , 波消失 ,较少部分听神经脱髓鞘严重可出现突聋。
Objective To study the auditory nerve demyelination in patients with multiple sclerosis (MS). Methods 21 cases of MS patients with abnormal brainstem response (BAEP) wave analysis of 23 cases, combined with MRI findings of auditory nerve demyelination lesions. Results Abnormal BAEP was found in 17 cases of unilateral and 4 cases in both sides, including 11 cases of abnormalities of wave latency (ILD) in both ears, 2 cases of disappearance of wave, 2 cases of bilateral undifferentiation, 3 cases of uncertain latency, 3 cases of latent period Extend in 3 cases. One unilateral subjective hearing impairment in 2 cases. In the meantime, BAEP revealed 10 cases of damage in the brainstem. MRI showed 5 cases of lesions in the brain stem. Conclusion Some MS patients have distal demyelinating damage of the auditory nerve. The main manifestations of I wave IL D abnormalities, part of the BAEP wave latency prolongation, the wave disappears, fewer parts of the auditory nerve denervation serious sudden deafness.