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目的探讨补铁对运动性贫血大鼠心肌线粒体呼吸链功能的影响。方法将雄性Wistar大鼠32只随机分为4组(n=8):训练组(T)、小剂量补铁+训练组(S+T)、中剂量补铁+训练组(M+T)和大剂量补铁+训练组(L+T),各组大鼠均进行递增负荷运动训练8周,每周训练6天,补铁大鼠从第5周开始补铁。力竭运动后即刻取样,差速离心法提取心肌线粒体。分光光度法测定线粒体呼吸链酶复合体Ⅰ~Ⅳ(CⅠ~Ⅳ)活性。结果与T组相比,S+T组和M+T组心肌线粒体呼吸链CⅠ~CⅣ活性均显著提高(P<0.01),L+T组心肌线粒体呼吸链CⅡ和CⅢ活性均显著提高(P<0.05)。结论大强度运动训练可导致大鼠缺铁性贫血的发生,训练期间复合补铁可提高大鼠血红蛋白、血清铁含量,并可提高大鼠心肌线粒体呼吸链功能及机体有氧工作能力,且中剂量补铁综合效应最佳。
Objective To investigate the effect of iron supplementation on myocardial mitochondrial respiratory chain in exercise-induced anemia rats. Methods Twenty-two male Wistar rats were randomly divided into 4 groups (n = 8): training group (T), low-dose iron supplementation training group (S + T), medium dose iron supplementation training group (M + T) And high-dose iron supplementation + training group (L + T). Rats in each group were subjected to incremental exercise training for 8 weeks and training for 6 days per week. Iron supplementation rats started iron supplementation from the 5th week. Samples were taken immediately after exhaustive exercise and myocardial mitochondria were extracted by differential centrifugation. Spectrophotometric Determination of Mitochondrial Respiratory Chain Enzyme Complex Ⅰ ~ Ⅳ (C Ⅰ ~ Ⅳ) activity. Results Compared with T group, the activity of CⅠ-CⅣ in mitochondrial respiratory chain in S + T group and M + T group was significantly increased (P <0.01), and the activity of C Ⅱ and C Ⅲ in mitochondrial respiratory chain increased significantly in L + T group <0.05). Conclusion High intensity exercise training can lead to the occurrence of iron-deficiency anemia in rats. Compound iron supplementation can increase hemoglobin and serum iron content in rats during training, and improve myocardial mitochondrial respiratory chain function and aerobic capacity in rats The best combination of iron dose effect.