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目的探讨新疆地区维吾尔族与汉族慢性胃炎患者与幽门螺杆菌不同抗体的关系。方法纳入2014年1至8月新疆维吾尔自治区人民医院诊断为慢性胃炎的患者198例,维吾尔族96例,汉族102例,均行幽门螺杆菌、幽门螺杆菌分型检测及胃十二指肠镜检查并活检,用χ2检验分析两组间幽门螺杆菌不同抗体的阳性率是否存在差异,对有差异者进行相关性分析。结果本研究中幽门螺旋杆菌5种不同抗体阳性率,维吾尔族较汉族明显增高;维吾尔族与汉族间Cag A-128KD、Vac A-110KD、Vac A-90KD、Ure B-66KD及Ure A-30KD的阳性率比较,差异有统计学意义(P<0.001);Cag A-128KD、Vac A-110KD、Vac A-90KD、Ure B-66KD及Ure A-30KD与维吾尔族慢性胃炎患者相关,其中与Cag A-128KD密切相关(r=0.506、0.410、0.273、0.285、0.277,P<0.001、<0.001、<0.05、<0.05、<0.05)。结论维吾尔族慢性胃炎患者较汉族慢性胃炎患者幽门螺旋杆菌5种不同抗体阳性率明显高,维吾尔族慢性胃炎患者与Cag A-128KD密切相关。
Objective To investigate the relationship between different antibodies against Helicobacter pylori in Uygur and Han patients with chronic gastritis in Xinjiang region. Methods A total of 198 patients diagnosed as chronic gastritis from January to August 2014 in People’s Hospital of Xinjiang Uygur Autonomous Region were enrolled. 96 Uygur patients and 102 Han patients were enrolled. Helicobacter pylori, Helicobacter pylori typing and gastroduodenoscopy Check and biopsy, with χ2 test analysis of the two groups of H. pylori antibodies whether there is a difference between the positive rate of correlation were analyzed. Results The prevalence of 5 different antibodies against Helicobacter pylori in our study was significantly higher than that of the Han nationality in Uygur nationality. The positive rates of Cag A-128KD, Vac A-110KD, Vac A-90KD, Ure B-66KD and Ure A-30KD (P <0.001). Cag A-128KD, Vac A-110KD, Vac A-90KD, Ure B-66KD and Ure A-30KD were associated with patients with Uygur chronic gastritis, Cag A-128KD (r = 0.506,0.410,0.273,0.285,0.277, P <0.001, <0.001, <0.05, <0.05, <0.05). Conclusions The positive rates of 5 kinds of antibodies against Helicobacter pylori in Han patients with chronic gastritis are significantly higher in Uygur patients with chronic gastritis. Uygur patients with chronic gastritis are closely related to Cag A-128KD.