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应用免疫组织化学方法，对５０例涎腺腺癌患者及２５例正常涎腺组织中的Ｃ－ｅｒｂＢ－２癌基因蛋白表达产物进行检测。结果发现：在涎腺腺癌中有２ｌ例显示Ｃ－ｅｒｂＢ－２蛋白表达阳性反应，而正常涎腺组织均为阴性反应，而且Ｃ－ｅｒｂＢ－２的表达程度与涎腺腺癌的临床分期、病理组织分化及患者的预后密切相关。提示，癌基因Ｃ－ｅｒｂＢ－２蛋白表达产物的检测可能对判断涎腺腺癌的恶性程度和预后有一定的意义。
The expression of C-erbB-2 oncogene protein in 50 patients with salivary gland adenocarcinoma and 25 normal salivary glands was detected by immunohistochemistry. The results showed that: 21 cases of salivary gland adenocarcinoma showed positive expression of C-erbB-2 protein, while the normal salivary gland tissue were negative, and the expression of C-erbB-2 and the clinical stage of salivary gland adenocarcinoma , Pathological tissue differentiation and prognosis of patients are closely related. These results suggest that the detection of oncogene C-erbB-2 protein expression may have some significance in judging the malignancy and prognosis of salivary gland adenocarcinoma.