抗菌药物的相互作用是目前临床用药研究的重要课题之一。了解这些作用规律有助于合理使用药物,避免不良反应,发挥更大的药效。相互作用产生的效果可归纳为两个主要方面:有益的相互作用与不利的相互作用。一、有益的相互作用两种或两种以上抗菌药物联合应用,导致药效增强,更有效地消灭病原生物。产生协同的机制大体有以下几个方面。 (一)两种或两种以上抗菌药物作用在细菌代谢的不同环节。细菌的生长繁殖以及生存有赖于不断地进行核酸、蛋白质等的生物合成。一旦合成 The interaction of antibacterial drugs is one of the important topics in clinical drug research. Understanding these rules of action helps to rationalize the use of drugs, avoid adverse reactions, and exert greater efficacy. The effects of interaction can be summarized in two main areas: beneficial interaction and adverse interaction. First, the beneficial interaction of two or more antimicrobial drugs combined application, resulting in enhanced efficacy, more effective elimination of pathogens. The mechanisms that produce synergies generally have the following aspects. (A) two or more antibacterial drugs in different parts of the metabolism of bacteria. The growth, reproduction and survival of bacteria rely on the ongoing biosynthesis of nucleic acids, proteins and the like. Once synthesized