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为研究ICE在肾透明细胞癌组织中的表达情况,探讨其在肾细胞癌(RCC)发生中的作用。采用免疫组织化学LSAB法对41例肾透明细胞癌及21例癌旁正常肾组织进行检测。结果ICE均为胞浆表达。正常肾组织阳性细胞含量为59.8%,RCC组织阳性细胞含量为10.4%,二者有统计学显著差异,P<0.001;肿瘤组织的ICE表达随病理核分级的增高而降低。结果提示:ICE在肾透明细胞癌组织中低表达,是RCC发生、发展的重要原因。
To investigate the expression of ICE in renal clear cell carcinoma and its role in the development of renal cell carcinoma (RCC). Immunohistochemical LSAB method in 41 cases of renal clear cell carcinoma and 21 cases of adjacent normal renal tissue were detected. ICE results were cytoplasmic. The positive cells in normal renal tissue were 59.8%, the positive cells in RCC were 10.4%, there was a statistically significant difference (P <0.001). ICE expression in tumor tissue decreased with the increase of pathological nuclear grade. The results suggest that low expression of ICE in renal clear cell carcinoma is an important reason for the occurrence and development of RCC.