許多學者們,特別是蘇聯學者們對於大腦皮層興奮和抑制的基本規律,在免疫過程中的重要性作了很多的研究。例如В.П.Тулъчинская氏以活布魯氏桿菌菌苗在豚鼠不同的神經狀態下來進行試驗,可以看到,注射咖啡因時,豚鼠的吞噬作用、凝集及沉澱抗體的產生,皆較對照組出現早,但降低也快;而在注射溴化鈉的豚鼠中,則得到相反的結果。它用小白鼠作試驗時也能得到同樣結果。此外Р.П.Каменечкая及Б.Л.Палант等氏以及我國鄭振羣曾做了類似的研究,也得到了相似的結果。相反地,也有一些學者們不能得到相同的結果。例如Б.Т.Аветикян和М.О.Мелкумян氏 Many scholars, especially the Soviet scholars, have done a lot of research on the importance of the basic rules of excitability and inhibition of the cerebral cortex in the immune process. For example, in the case of В.П.Тулъчинская’s live B. brucei vaccine in different neural states in guinea pigs, it can be seen that during the injection of caffeine, guinea pig phagocytosis, agglutination and precipitated antibody production than the control group Appeared early but decreased rapidly; while in sodium bromide injected guinea pigs, the opposite result was obtained. It can also get the same result when tested in mice. In addition, Р.П.Каменечкая and Б.Л.Палант et al. And Zheng Zhenqun in our country have done similar research and obtained similar results. On the contrary, some scholars can not get the same result. For example, Б.Т.Аветикян and М.О.Мелкумян