论文部分内容阅读
目的探讨甲氨蝶呤联合米非司酮保守治疗未破裂异位妊娠的疗效。方法选择未破裂异位妊娠患者114例,按照入院单双日分为对照组和治疗组,每组57例,对照组一次性给予甲氨蝶呤50 mg/m(2按体表面积计算用量)肌内注射,7 d后若血β-HCG下降<15%,重复给药1次;治疗组给予甲氨蝶呤20 mg/d肌内注射,口服米非司酮50 mg/次,2次/d,5 d为一个疗程。分别于给药后4、7 d检测并比较两组患者腹痛、妊娠包块大小、血黄体酮和β-HCG值。结果治疗组治疗后治愈,率为98.2%,且在包块直径、血黄体酮、血β-HCG方面显著好于对照组,差异有统计学意义(P<0.05),两组不良反应比较,差异无统计学意义(P>0.05)。结论甲氨蝶呤联合米非司酮保守治疗未破裂异位妊娠疗效优于甲氨蝶呤,且不良反应小,值得在临床中推广应用。
Objective To investigate the efficacy of methotrexate combined with mifepristone in conservative treatment of unruptured ectopic pregnancy. Methods A total of 114 patients with unruptured ectopic pregnancy were enrolled and divided into control group and treatment group on the basis of admission day and night, 57 cases in each group. The control group received methotrexate 50 mg / m (2) Intramuscular injection, blood β-HCG decreased <15% 7 days after repeated administration of 1; the treatment group was given methotrexate 20 mg / d intramuscular injection of oral mifepristone 50 mg / time, 2 times / d, 5 d for a course of treatment. The abdominal pain, the size of pregnancy mass, blood progesterone and β-HCG were detected and compared on the 4th, 7th day after administration respectively. Results The treatment group was cured after treatment, the rate was 98.2%, and in terms of mass diameter, blood progesterone and blood β-HCG was significantly better than the control group, the difference was statistically significant (P <0.05), two groups of adverse reactions, The difference was not statistically significant (P> 0.05). Conclusion Methotrexate combined with mifepristone conservative treatment of unruptured ectopic pregnancy better than methotrexate, and adverse reactions, it is worth promoting in the clinical application.