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目的 总结72例卵巢恶性生殖细胞肿瘤的治疗及预后。方法 1978年至1991年我院共收治卵巢恶性生殖细胞肿瘤72例,占同期收治的卵巢恶性肿瘤总数的22.15％。Ⅰ期43例,Ⅱ期5例,Ⅲ期15例,Ⅳ期8例。实施以手术为主加化疗或/和放疗。结果 全组5年生存率54.2％,其中无性细胞瘤81.52％,未成熟畸胎瘤53.30％,混合性生殖细胞瘤33.33％,内胚窦瘤22.20％,胚胎癌0。结论 影响其愈后的诸因素中,除临床期别,病理类型外,恰当的手术切除范围,术后多疗程的联合化疗显得尤为重要。对年青需保留生育功能的无性细胞瘤患者,术后化疗取代传统的放疗较为妥当。
Objective To summarize the treatment and prognosis of 72 cases of malignant ovarian germ cell tumors. Methods From 1978 to 1991, 72 cases of ovarian malignant germ cell tumors were treated in our hospital, accounting for 22.15% of the total number of ovarian malignancies treated in the same period. Stage Ⅰ 43 cases, stage Ⅱ 5 cases, stage Ⅲ 15 cases, stage Ⅳ 8 cases. The implementation of surgery plus chemotherapy or / and radiotherapy. Results The 5-year overall survival rate was 54.2%, including 81.52% of non-cancerous cells, 53.30% of immature teratomas, 33.33% of mixed germinomas, 22.20% of endodermal sinus tumors, and 0 of embryonic carcinomas. Conclusions Among the factors that affect the prognosis, except for the clinical stage and pathological type, the appropriate range of surgical resection and multi-course combined chemotherapy is particularly important. For young patients who need to retain the reproductive function of patients with dysgerminoma, postoperative chemotherapy to replace traditional radiotherapy is more appropriate.