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本文以心电图、心脏收缩时间间期及心肌病理检查等指标研究柔红霉素(DNR)、阿霉素(ADM及阿克拉霉素-B(ACM-B)三种蒽环类药物对家兔的急性心脏毒性。结果表明 ADM 和 ACM-B 可引起心律失常,三种药物均引起心功能损伤和心肌毒性变化。
In this paper, electrocardiogram, systolic time and myocardial pathological examination and other indicators of daunorubicin (DNR), doxorubicin (ADM and aclacinomycin-B (ACM-B) three anthracyclines on rabbits Of acute cardiotoxicity.The results show that ADM and ACM-B can cause arrhythmia, three kinds of drugs cause cardiac dysfunction and myocardial toxicity changes.