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帕金森病黑质细胞多巴胺能神经元缺失的原因至今仍是神经病学的重要研究课题。近年来随着自由基理论研究的不断深入，对帕金森病的发病机制也有了新的认识。本文就帕金森病自由基病理生理、自由基对黑质细胞损害的病理机制及抗氧化治疗作一简要综述。
The reason for the loss of dopaminergic neurons in Parkinson’s disease substantia nigra is still an important research topic in neurology. In recent years, with the deepening of free radical theory, the pathogenesis of Parkinson’s disease also has a new understanding. In this paper, the pathophysiology of free radical in Parkinson’s disease, free radicals on the pathological mechanism of nigral cell damage and anti-oxidation therapy for a brief review.