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目的 研究A型行为 (TAB)与脑梗死及血液流变学的关系 ,为脑梗死的预防提供依据。方法 采用 1∶1配对病例对照设计 ,应用全国心身医学协作组编制的“A型行为类型问卷”对 2 45例脑梗死患者及 2 45名健康对照进行问卷调查 ;并随机筛选出A型行为脑梗死患者 (TAB组 )和与之相匹配的非A型行为脑梗死患者 (非TAB组 )各 5 0例 ,同时随机选取TAB和非TAB健康人员各 5 0名作为对照组 ,4组受试者均于晨 6时空腹抽静脉血进行血液流变学检测。结果 脑梗死组TAB者占 79.5 % ,对照组TAB者占 5 4.8% ,优势比值为 3.16 (95 %可信限为 2 .0 6～ 4.84,P <0 .0 0 5 )。TAB组患者全血低切粘度 (1s- 1 )、血浆粘度 (10 0s- 1 )、红细胞聚集指数及血浆纤维蛋白原显著高于非TAB组及对照组 (P <0 .0 5 )。结论 A型行为可能是导致脑梗死的危险因素之一 ;对A型行为给与适当的干预 ,应是脑梗死一级预防的内容之一。
Objective To study the relationship between type A behavior (TAB) and cerebral infarction and hemorheology, and to provide a basis for the prevention of cerebral infarction. Methods A 1: 1 matched case-control study was designed. A type A behavioral questionnaire prepared by the National Psychosomatic Medical Collaboration Group was used to survey 2 45 cerebral infarction patients and 2 45 healthy controls. A type A behavioral brain was randomly selected Fifty patients with infarction (TAB group) and matched non-A type cerebral infarction patients (non-TAB group) were randomly selected. Fifty TAB and non-TAB healthy individuals were randomly selected as control group and four groups All were fasting venous blood at 6 am for hemorrheology. Results TAB in cerebral infarction group accounted for 79.5%, TAB in control group accounted for 4.8%, the odds ratio was 3.16 (95% confidence interval was 2.06 ~ 4.84, P <0.05). Low blood viscosity (1s-1), plasma viscosity (10s-1), erythrocyte aggregation index and plasma fibrinogen in TAB group were significantly higher than those in non-TAB group and control group (P <0.05). Conclusions Type A behavior may be one of the risk factors for cerebral infarction. Appropriate intervention on type A behavior should be one of the primary prevention measures of cerebral infarction.