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目的 观察高脂蛋白血症患者血浆P 选择素表达及普伐他汀的作用。方法 应用酶联免疫吸附法检测 31例高脂蛋白血症患者服用普伐他汀前后血浆P 选择素水平 ,并与 35例血脂正常者对照。结果 高脂蛋白血症组血清总胆固醇、低密度脂蛋白胆固醇及血浆P 选择素水平均显著高于正常对照组 (P <0 .0 1) ,普伐他汀治疗后血浆P 选择素水平显著下降 (P <0 .0 1)。结论 高脂蛋白血症患者血浆P -选择素表达异常可能参与高脂蛋白血症的致动脉粥样硬化作用。
Objective To observe the plasma P-selectin expression in patients with hyperlipoproteinemia and the effect of pravastatin. Methods Plasma P-selectin levels in 31 patients with hyperlipoproteinemia before and after taking pravastatin were measured by enzyme-linked immunosorbent assay (ELISA) and compared with 35 patients with normal lipids. Results The levels of serum total cholesterol, low density lipoprotein cholesterol and plasma P-selectin in hyperlipoproteinemia group were significantly higher than those in normal control group (P <0.01), and the plasma P-selectin level was significantly decreased after pravastatin treatment (P <0. 01). Conclusion The abnormal plasma P - selectin expression in patients with hyperlipoproteinemia may be involved in the atherosclerosis effect of hyperlipoproteinemia.