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以魔芋葡甘聚糖(KGM)为缓释药膜,分析模型药物—尼莫地平的体外释放特性。筛选并确定KGM浓度、DM-SO添加量、载药混合时间和静置时间4个因素的中心组合试验设计,以尼莫地平(NMP)的缓释度为考察指标,采用响应面优化KGM缓释药膜的制备工艺。结果表明:4个因素对药膜缓释尼莫地平均有显著影响,依次为静置时间>KGM浓度>DMSO添加量>载药混合时间,且最优条件为3.0%(w/v)KGM、0.5 mL DMSO、载药混合12 min、静置77 min。制备的药膜表面平整光滑,载药量为(1.63±0.01)%,尼莫地平缓释度为93.169%。
The in vitro release characteristics of the model drug, nimodipine, were analyzed with konjac glucomannan (KGM) as sustained release membrane. Screening and determining the concentration of KGM, the amount of DM-SO, drug loading time and resting time of four combinations of experimental design center to nimodipine (NMP) for the study of sustained-release index, response surface optimization of KGM Preparation of release film. The results showed that the four factors had significant effects on the average sustained release of nimodipine, which were: standing time> KGM concentration> DMSO dosage> loading time, and the optimal condition was 3.0% (w / v) KGM , 0.5 mL DMSO, drug mixed for 12 min, stand for 77 min. The preparation of the membrane surface smooth, drug loading (1.63 ± 0.01)%, nimodipine sustained-release was 93.169%.