[目的]探讨中药成份复方(丹参酚酸B、山楂黄酮)对大鼠非酒精性脂肪性肝病相关因素的影响。[方法]大鼠被随机分为:①正常对照组,普通鼠饲料喂养;②模型组,高脂饲料喂养;③中药预防组,高脂饲料喂养的同时加每天1次灌服丹参酚酸B(200mg/kg)和山楂黄酮(40mg/kg);④中药治疗组,高脂饲料喂养4周后加每天1次灌服丹参酚酸B(200mg/kg)和山楂黄酮(40mg/kg);⑤西药组:高脂饲料喂养4周后加每天1次灌服二甲双胍片(0.5g/kg)。实验共12周。[结果]①12周时中药预防组大鼠血清脂联素含量较模型组显著升高(P<0.01);②各组大鼠血清游离脂肪酸和肿瘤坏死因子-α含量比较差异无统计学意义;③与模型组相比,6、8、12周时,中药预防组和中药治疗组大鼠肝组织三酰甘油含量明显降低(P<0.01)。[结论]丹参酚酸B和山楂黄酮联用对大鼠非酒精性脂肪性肝病相关因素具有干预作用。 [Objective] To investigate the effect of traditional Chinese medicine compound (salvianolic acid B, hawthorn flavone) on related non-alcoholic fatty liver disease in rats. [Methods] The rats were randomly divided into: ① normal control group, ordinary rats fed diet; ② model group, high-fat diet; ③ Chinese medicine prophylaxis group, fed with high fat diet plus once daily dose of salvianolic acid B (200mg / kg) and hawthorn flavone (40mg / kg); (4) Chinese medicine group and high fat diet were fed with salvianolic acid B (200mg / kg) and hawthorn flavone (40mg / kg) ⑤ western medicine group: high-fat diet for 4 weeks plus 1 daily dose of metformin tablets (0.5g / kg). The experiment was 12 weeks in total. [Results] ① At 12 weeks, the level of serum adiponectin in Chinese medicine prevention group was significantly higher than that in model group (P <0.01); ② There was no significant difference in serum free fatty acid and tumor necrosis factor- ③ Compared with the model group, the content of triglyceride in the liver tissue of the Chinese medicine prophylaxis group and the Chinese herbal medicine treatment group was significantly decreased at 6, 8 and 12 weeks (P <0.01). [Conclusion] Salvia miltiorrhiza B and hawthorn flavonoids can interfere with the related factors of nonalcoholic fatty liver disease in rats.