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目的分析146例HIV/AIDS外周血CD4+T淋巴细胞的变化,为艾滋病防治工作提供科学依据。方法采用流式细胞术检测HIV/AIDS的外周血CD4+T淋巴细胞数并统计分析其特征。结果 146例HIV/AIDS中,初次检测的CD4+T淋巴细胞平均数为(346.40±182.14)个/μL;其中,CD4+T淋巴细胞<200个/μL的有40人,占27.4%;200~350个/μL的有43人,占29.5%;不同性别、年龄CD4+T淋巴细胞计数比较差异无统计学意义。未接受抗病毒治疗的艾滋病患者,在不同免疫状态的各组之间,CD4+T淋巴细胞绝对值在不同范围内的下降数有统计学差异(F=20.505,P<0.05);接受了抗病毒治疗的艾滋病患者,CD4+T淋巴细胞普遍可以回升,表明抗病毒治疗是有效的。结论 146例HIV/AIDS的CD4+T淋巴细胞免疫水平普遍偏低,初次检测中有27.4%新发现感染者已进入艾滋病期,对HIV感染者进行定期检测T淋巴细胞,对制定预防控制措施、监测病情的进展和制定治疗方案均具有重要的临床意义。
Objective To analyze the changes of CD4 + T lymphocytes in 146 cases of HIV / AIDS peripheral blood and provide a scientific basis for AIDS prevention and treatment. Methods The number of CD4 + T lymphocytes in peripheral blood of HIV / AIDS patients was detected by flow cytometry and their characteristics were analyzed statistically. Results Among the 146 cases of HIV / AIDS, the average number of CD4 + T lymphocytes detected for the first time was (346.40 ± 182.14) / μL; among them, 40 were CD4 + T lymphocytes <200 cells / μL, accounting for 27.4%; 200 ~ 350 / μL of 43 people, accounting for 29.5%; different gender, age, CD4 + T lymphocyte count was no significant difference. There was a statistically significant difference in the absolute value of CD4 + T lymphocytes among different groups of AIDS patients who did not receive antiviral therapy (F = 20.505, P <0.05) Virus-treated AIDS patients, CD4 + T lymphocytes can generally rise, indicating that antiviral therapy is effective. Conclusion The immunization level of CD4 + T lymphocytes in 146 cases of HIV / AIDS is generally low. 27.4% of the newly detected HIV / AIDS patients in the initial test have entered the AIDS stage. T lymphocytes are regularly detected in HIV-infected persons, and the prevention and control measures, Monitoring the progress of the disease and the development of treatment programs are of important clinical significance.