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从1803年发现象牙化石中含有氟以来,人们认识到动物组织中存在氟,但对氟的生物学意义仍然是不清楚的。目前使用灵敏分析方法对于各种骨骼和牙齿中氟的测定时,已经确认氟在骨骼和牙齿的生长形成中起十分重要的作用。与此同时,人们又发现在食物(包括饮水)中氟量过少,可以影响牙齿的形成,易患龋。而在食物中存在足量的氟化物时显著地降低了儿童牙齿的龋患率。这一系列的发现证明了氟是人类健康所必需的微量元素之一。本文就氟和氟化物的生物化学作用作一些简要的介绍。
Since the discovery of fluorine in ivory fossils in 1803, it has been recognized that there is fluoride in animal tissues, but the biological significance of fluorine remains unclear. The current use of sensitive analytical methods for the determination of fluoride in various bones and teeth has confirmed that fluorine plays a very important role in the growth of bones and teeth. At the same time, people also found that too little fluoride in food (including drinking water), can affect the formation of teeth, susceptible to caries. In the presence of a sufficient amount of fluoride in the diet, the dental caries prevalence in children is significantly reduced. This series of findings prove that fluorine is one of the trace elements essential for human health. This article gives some brief introduction to the biochemistry of fluorine and fluoride.