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应用放射性同位素（４５ＣａＣＯ３）方法研究健康豚鼠和链霉素肌注豚鼠球囊、椭圆囊耳石膜、锤骨和股骨在不同时间内对４５Ｃａ吸收水平的动态变化，了解链霉素对耳石膜钙含量的影响，以探讨链霉素前庭中毒的机理。研究结果说明耳石膜的钙是在不断更新的，它与骨组织一样都是动态结构。球囊与椭圆囊耳石膜４５Ｃａ吸收水平有差别，推测内淋巴中Ｃａ２＋含量会有差别，其内淋巴内环境也可能会有差别。链霉素使球囊和椭圆囊耳石膜吸收４５Ｃａ的能力下降，引起耳石膜钙代谢的紊乱，耳石钙含量下降，还可能引起耳石器内淋巴内环境发生改变，导致耳石器功能发生障碍，此可能是链霉素引起前庭中毒的机理之一。
The radioactive isotope (45CaCO3) method was used to study the dynamic changes of 45Ca absorbance in healthy guinea pigs and streptomycin-injected guinea pigs, ellipsoid otoliths, malleus and femur at different times, and to understand the effect of streptomycin on otolith Calcium content, to explore the mechanism of streptomycin vestibular poisoning. The results show that the otolith membrane calcium is constantly updated, it is the same as the dynamic structure of bone tissue. Balloon and ellipsoid capsule 45Ca absorption levels are different, speculated that there is a difference in endolymph Ca2 + content, the lymphatic environment may also be different. Streptomycin balloon and oval capsule otolith membrane ability to absorb 45Ca decreased, causing otolith membrane calcium disorders, decreased otolith calcium content may also cause changes in the otolith device within the lymphatic environment, resulting in otolith function This may be one of the mechanisms by which streptomycin causes vestibular toxicity.