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目的探讨2009年新型甲型H1N1流感患者病毒RNA检出率与人群年龄分布和病程变化的关系。方法选取广州地区新型甲型H1N1临床病例共248例,对151例进行病程动态咽拭子采样833份,统计分析患病人群年龄分布和采用荧光定量RT-PCR方法对不同病程的患者咽拭子标本进行甲型H1N1流感病毒RNA的检测,并采用趋势χ2检验探讨标本阳性率与不同发病时间的关系。结果发病人群以青壮年为主,主要集中在10~20岁(57.26%)和20~30岁(22.18%)两个年龄段。对咽拭子标本阳性率随发病时间的变化进行趋势χ2结果显示标本阳性率随着病程的延长而下降(χ2=9.784,P=0.002)。讨论此次研究表明新型H1N1流感患者主要集中在青壮年人群中,且有最长可达10天以上的病程,标本阳性率随着病程的延长而下降。
Objective To investigate the relationship between the detection rate of virus RNA in 2009 new type A (H1N1) virus and the population age distribution and course of disease. Methods A total of 248 cases of new type A H1N1 clinical cases in Guangzhou were selected and 151 cases were subjected to dynamic throat swab sampling in 833 cases. The age distribution of the patients was statistically analyzed and the throat swabs Specimens of influenza A (H1N1) virus RNA detection, and the trend χ2 test to explore the positive rate of specimens and the relationship between the different onset time. Results Most of the patients were young adults, mainly in the age of 10-20 years (57.26%) and 20-30 years (22.18%). The positive rate of throat swab specimens with the time of onset trend χ2 results showed that the positive rate of specimens decreased with the duration of the disease (χ2 = 9.784, P = 0.002). Discussion The study showed that the new H1N1 influenza patients mainly concentrated in young adults, and the longest up to 10 days duration, the positive rate of specimens decreased with the duration of the disease.