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早先认为ITP系一种IgG抗体介导而引致血小板毁坏的疾患。作者用定量抗球蛋白消耗试验测定67例成人ITP血小板结合的IgG(抗血小板抗体,PBIgG),观察血小板抗体值与类固醇治疗及脾切除的疗效之间的相关性。67例病人血小板计数均<50×10~9/l,PBIgG正常值的上限为14.8ng/10~6血小板。全部病人先给予强的松1mg/kg/日,持续2周,然后减至20-30mg/日,而后再在6-8周内逐渐减完。开始治疗后2周血小板数未升至正常(>150×10~9/l)(无效)或2周升至正常,但逐渐减量时又下降者(部分有效),均属治疗失败。停止治疗后血小板数仍正
ITP was previously thought to be an IgG-mediated disorder that causes platelet destruction. The authors used a quantitative antiglobulin depletion assay to measure the association of platelet-associated IgG (anti-platelet antibody, PBIgG) in 67 adults with ITP and the efficacy of steroid therapy and splenectomy. The platelet counts of 67 patients were all <50 × 10 ~ 9 / l, and the upper limit of normal PBIgG was 14.8ng / 10 ~ 6 platelets. All patients given prednisone 1mg / kg / day for 2 weeks, then reduced to 20-30mg / day, and then gradually reduced within 6-8 weeks. The number of platelets did not rise to normal (> 150 × 10 ~ 9 / l) (inactive) or rose to normal within 2 weeks after the start of treatment, but decreased again and again (partially) after gradual reduction. After stopping treatment, the number of platelets is still positive