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探讨颅内生殖细胞瘤的临床治疗方法。方法 对 10例颅内生殖细胞瘤进行前瞻性治疗研究。治疗采取肿瘤局灶小野放射治疗 ,同时联合顺铂、足叶乙甙化疗。放射治疗采用6MVX射线和 16MeV电子线 ,X射线剂量为 40～ 5 5Gy ,电子线剂量为 2 5Gy ;化疗为 3个疗程。 结果 肿瘤完全消失 8例 ,瘤体缩小 90 %以上 2例 ,无 1例复发。随访 1.0～ 4.5年 (中位随访时间 3 .2年 ) ,全部病例生存状况良好。结论 局灶放射治疗与化疗联合可使两者治疗作用相加、毒副作用相减 ,是颅内生殖细胞瘤的有效治疗方法。
Explore the clinical treatment of intracranial germ cell tumors. Methods A prospective treatment study was performed on 10 cases of intracranial germinoma. The treatment was performed with oncological onset of Ono-radiotherapy, combined with cisplatin, and etoposide chemotherapy. Radiotherapy uses 6MV X-rays and 16MeV electrons, X-ray doses are 40 to 55Gy, electron beam doses are 25Gy, and chemotherapy is 3 courses. Results The tumor completely disappeared in 8 cases, the tumor was reduced by more than 90% in 2 cases, and no recurrence occurred. During follow-up of 1.0 to 4.5 years (median follow-up time of 3.2 years), all patients survived well. Conclusion The combined use of focal radiotherapy and chemotherapy can increase the therapeutic effects of the two combined treatments and reduce toxic and side effects. It is an effective treatment for intracranial germ cell tumors.