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新近研究证明,SLE患者的抗核糖体抗体与分别称为P0、P1和P2(总称P蛋白)的三种大核糖体亚单位磷酸蛋白反应.有意义的是,有这种抗体的病人常发生狼疮性精神病,并已证明血清抗P蛋白抗体的水平与狼疮性精神病的临床活动性有关.本文报道3例无精神病症状的SLE病人,皆为女性,尿液分析和血清生化学检验都正常,均具典型LE皮疹及阳性LBT,但体检未显示其它异常.对患者血清标本应用HEP-2细胞为底物行间接免疫荧光检查,结果示细胞浆和核仁强染色,这些染色均在30分钟内被500mg/L浓度的核糖核酸酶完全消化,提示抗体结合的是与RNA相关的抗原.以兔胸腺丙酮粉为抗原对3份血清标本作双向免疫
Recent studies have demonstrated that anti-ribosomal antibodies in SLE patients react with three large ribosomal subunit phosphoproteins, designated P0, P1 and P2, respectively (collectively P protein). What is significant is that patients with this antibody frequently develop Lupus and mental illness, and has proved that the serum level of anti-P protein antibodies and clinical activity of lupus psychosis related to this article reported three cases of SLE patients without psychotic symptoms, all women, urine analysis and serum biochemical tests are normal, All had typical LE rashes and positive LBT, but no other abnormalities were found in the physical examination.Indirect immunofluorescence assay using HEP-2 cells as the substrate in the serum samples of patients showed strong staining of cytoplasm and nucleolus, all in 30 minutes Was completely digested with ribonuclease at a concentration of 500 mg / L, suggesting that the antibody bound to the antigen was RNA-related antigen. Three serum samples were immunized with acetone thymus