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夜间酸突破现象(NAB)是指在应用质子泵抑制剂(PPI)的情况下,夜间(当晚22时至次日早上8时)胃内pH值小于4．0的时间持续超过60min,其确切的发病机制尚不清楚,可能与夜间激活的质子泵数量较少、夜间迷走神经兴奋性高、幽门螺杆菌(H．pylori)感染以及代谢酶CYP2C19的基因类型等因素有关。NAB与酸相关性疾病密切相关,治疗对策可根据不同疾病的pH值,选择PPI联合应用H_2受体阻滞剂(H_2RA)、增加PPI剂量、调整给药方式等不同方案。
Nocturnal acid breakthrough (NAB) refers to the use of proton pump inhibitor (PPI) at night (22 o’clock to 8 o’clock the next morning) intragastric pH value of less than 4.0 for more than 60min, the exact The pathogenesis is unclear, which may be related to the number of proton pump activated at night, high excitability of vagus nerve at night, H.pylori infection and the genotype of CYP2C19, a metabolic enzyme. NAB and acid-related diseases are closely related to treatment options according to different diseases, choose PPI combined H_2 receptor blocker (H_2RA), increase the dose of PPI, adjust the mode of administration and other programs.