自青霉素应用于临床以来,在治疗领域中,抗菌素已被公认为疗效卓著的药物。近二十年来新的抗菌素陆续被发现、合成,其临床应用也日益广泛。随着抗菌素的广泛应用,在实际工作中亦出现了一些新的问题,例如:耐药性菌株的增加、抗菌素的过敏性反应以及菌丛失调等问题。在某些实验中已指出抗菌素对机体代谢及抗体形成也有影响。 Since penicillin has been used clinically, antibiotics have been recognized as effective therapeutic agents in the therapeutic field. In recent twenty years, new antibiotics have been discovered and synthesized one after another, and their clinical application is also increasingly widespread. With the wide application of antibiotics, some new problems have appeared in the practical work, such as the increase of drug-resistant strains, the allergic reaction of antibiotics and the imbalance of bacterial flora. It has been pointed out in some experiments that antibiotics also have effects on the body’s metabolism and antibody formation.