论文部分内容阅读
目的 :探讨兔迷走及交感神经对维持消化间期胆囊内压 ( GP)的作用。方法 :健康成年家兔47只 ,禁食但自由饮水 1 5～ 1 8h后 ,乌拉坦静脉麻醉 ,三碘季胺酚肌松 ,人工呼吸。胆囊 ( GB)内置入蛙膀胱囊方法测 GP。结果 :消化间期 ,兔 GB维持稳定的基础压 ,静脉注射生理盐水后 30 min内 GP无明显变化。电刺激 ( 2 m A,1 0 Hz,2 ms,1 0 s)迷走神经远端引起 GP升高 ,而静脉注射阿托品 ( 0 .2 mg/kg)后再刺激迷走神经 ,GP不再变化 ;单纯剪断两侧颈部迷走神经或静脉注射阿托品 ( 0 .2 mg/kg)后 ,GP无明显变化。切断第一胸髓后 GP明显下降 ;静脉注射去甲肾上腺素 ( NE) ( 0 .0 1 mg/kg)后 GP升高 ;注射酚托拉明 ( 1 .5mg/kg)后GP下降 ;而静脉注射心得安 ( 1 .5mg/kg)后 GP改变不明显。 结论 :兔消化间期 GP的维持主要与交感神经及外周α受体有关 ,迷走神经的作用似乎不大。
Objective: To investigate the effect of vagal and sympathetic nerves in rabbits on the maintenance of intercostal gallbladder pressure (GP). Methods: Forty-seven healthy adult rabbits were anesthetized by intravenous urethane, triamcinolone acetonide and artificial respiration after fasting but free water for 15 to 18 hours. Gallbladder (GB) built into the frog bladder bladder method for the determination of GP. Results: In the interdigestive period, GB of rabbits maintained a steady basal pressure. There was no significant change of GP within 30 min after intravenous injection of saline. Electrical stimulation (2 m A, 1 0 Hz, 2 ms, 10 s) induced a GP increase in the distal vagus nerve, while atropine (0.2 mg / kg) was administered intravenously to stimulate the vagus nerve without changes in GP. There was no significant change in GP after bilateral neck vagus nerve or intravenous injection of atropine (0.2 mg / kg). After the first thoracic cord was severed, GP decreased significantly; GP increased after intravenous injection of norepinephrine (0 01 mg / kg); GP decreased after injecting phenolplatin (1.5 mg / kg) After intravenous propranolol (1 .5mg / kg) GP change was not obvious. CONCLUSION: The maintenance of GP in rabbits during interphase is mainly related to the sympathetic nerve and the peripheral α receptor, and the effect of the vagus nerve does not appear to be significant.