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骨髓含有内皮祖细胞,能够迁移至外周血并分化为成熟内皮细胞,参与胚胎时期的血管生成、出生后的微血管新生以及肿瘤组织的发生。体内内皮祖细胞数量和活性受多种生理性及病理性因素的的影响。体外扩增后回输体内可以修复受损组织、器官的血管,促进器官功能恢复;抑制其活性,在一定程度上可以抑制肿瘤组织的生长。内皮祖细胞为缺血性疾病以及肿瘤的治疗提供了另一新的靶点。
Bone marrow contains endothelial progenitor cells that migrate to peripheral blood and differentiate into mature endothelial cells, participate in embryonic angiogenesis, postnatal microvascular angiogenesis and tumorigenesis. The number and activity of endothelial progenitor cells in vivo are influenced by a variety of physiological and pathological factors. After in vitro amplification, the transfused body can repair damaged blood vessels of organs and organs and promote the recovery of organ function; inhibit its activity and inhibit the growth of tumor tissue to a certain extent. Endothelial progenitor cells provide another new target for the treatment of ischemic diseases and tumors.