庆大霉素在临床上广泛用于治疗革兰氏阴性菌引起的严重感染症,但该药的治疗浓度范围狭窄,当其血清峰浓度大于12μg/ml时易招致肾脏的毒性反应;血清谷浓度超过2μg/ml时则可能增加听神经的毒性,故临床上在用庆大霉素作多剂量间歇静脉滴注时最好控制用药者的血清峰浓度不大于4～10μg/ml,并避免谷 Gentamicin is widely used clinically to treat severe infections caused by Gram-negative bacteria. However, the therapeutic concentration of gentamicin is narrow. When its peak serum concentration is more than 12μg / ml, it is easy to cause renal toxicity. Serum Valley Concentration of more than 2μg / ml may increase the toxicity of the auditory nerve, so the clinical use of gentamicin for intermittent intravenous infusion of multiple doses is best to control the drug serum concentration of not more than 4 ~ 10μg / ml, and to avoid the valley