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高血压患者的许多病理生理变化可能影响速尿的药物代谢动力学和药效学。本文研究速尿在发病期短并伴有血管受损的高血压患者中的药物代谢动力学及其排钠作用。给7例伴有血管并发症的严重高血压患者静脉注射速尿40毫克,用两室开放模型来描述血清中药物消失的规律。用薄层层析及萤光比色法测定血液和尿中的速尿浓度以及用β-葡萄糖醛酸酶培育法测定尿中的葡萄糖酸甙含量。速尿与蛋白结合力是用试管内血样本测定的。结果表明,在高血压患者中,速尿在血中的平
Many pathophysiological changes in hypertensive patients may affect the pharmacokinetics and pharmacodynamics of furosemide. This article studies furosemide in patients with short duration of onset and vascular damage in patients with hypertension and its pharmacokinetics of sodium. Serum 40 mg of furosemide were injected intravenously into 7 severe hypertensive patients with vascular complications. A two-compartment open model was used to describe the disappearance of the drug in the serum. The concentration of furosemide in blood and urine was determined by thin-layer chromatography and fluorescent colorimetric assay, and the content of glucosidase in urine was determined by β-glucuronidase incubation. Furosemide and protein binding were measured in in vitro blood samples. The results show that furosemide is flat in the blood in hypertensive patients