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目的探讨Y染色体微缺失对卵胞质内单精子注射(ICSI)胚胎发育和妊娠结局的影响。方法回顾19例Y染色体微缺失患者(研究组)进行的23个治疗周期的胚胎和临床结局资料,与同期无Y染色体微缺失(对照组)的少弱精子症或无精子症的86个治疗周期的相应资料进行比较,分析两组患者在受精率、卵裂率、优质胚胎率、生化妊娠率、临床妊娠率、胚胎种植率、早期流产率的差异。结果研究组和对照组相比,受精率(85.0%vs89.2%)、卵裂率(96.0%vs 95.3%)、优质胚胎率(68.3%vs 66.7%)、生化妊娠率(47.8%vs 50.0%)、临床妊娠率(43.5%vs 41.6%)、胚胎种植率(22.9%vs 20.8%)、早期流产率(10.0%vs 7.5%)差异比较无统计学意义(P>0.05)。结论 Y染色体微缺失对胚胎质量和妊娠结局无显著性影响。
Objective To investigate the effect of Y chromosome microdeletion on intracytoplasmic sperm injection (ICSI) embryo development and pregnancy outcome. Methods The embryo and clinical outcome data of 23 cycles of treatment in 19 patients with Y chromosome microdeletion (study group) were compared with 86 less azoospermia or azoospermia patients without Y chromosome microdeletions (control group) Cycle of the corresponding data were compared to analyze the two groups of patients in fertilization rate, cleavage rate, high quality embryo rate, biochemical pregnancy rate, clinical pregnancy rate, embryo implantation rate, early abortion rate differences. Results The rates of cleavage (96.0% vs 95.3%), high quality embryos (68.3% vs 66.7%), biochemical pregnancy rates (47.8% vs 50.0%) were significantly higher in study group than in control group The clinical pregnancy rate (43.5% vs 41.6%), embryo implantation rate (22.9% vs 20.8%) and early miscarriage rate (10.0% vs 7.5%) had no statistical significance (P> 0.05). Conclusion Y chromosome microdeletions have no significant effect on embryo quality and pregnancy outcome.