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长期培养起始细胞（ＬＴＣ－ＩＣ）是一群迄今为止经体外培养所获得的最幼稚的造血祖细胞。作者用正常人类骨髓基质细胞以及５株人或鼠的骨髓外纤维细胞作基底层，移种上ＣＤ／ＳＢＡ￣－细胞，进行持续８周的长期培养，获得了人类正常骨髓中的长期培养起始细胞；同时筛选出ＭＲＣ－５细胞株作为支持血细胞生成、分化的理想细胞株。
Long-term culture initiating cells (LTC-ICs) are the naive hematopoietic progenitor cells obtained by in vitro culture to date. Using normal human bone marrow stromal cells and 5 human or murine extramedullary fibroblasts as the basal layer, the authors transplanted CD / SBA-1 cells for long-term culture for 8 weeks to obtain long-term culture in human normal bone marrow Start cells; MRC-5 cell lines were screened at the same time as an ideal cell line to support hematopoiesis and differentiation.