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患者女,51岁。左侧颞部浅棕色斑疹20年,其上出现棕褐色丘疹1个月,无不适。皮损组织病理示:表皮角化过度,棘层肥厚,乳头瘤样增生,伴角囊肿、假性角囊肿的形成;角质层内可见黑素颗粒,黑素细胞散在分布于表皮各层,黑素细胞水平扩展,真、表皮界限不清;真皮内未见明显色素细胞巢,见淋巴细胞浸润。免疫组化示:HMB45和S-100蛋白(+),CK(+/-)。诊断:脂溢性角化病;原位黑素瘤。
Female patient, 51 years old. Left temporal lobe rash 20 years, appeared on the papaya papaya for 1 month, no discomfort. Pathological lesions showed: epidermal hyperkeratosis, acanthosis, papilloma-like hyperplasia, associated cysts, pseudocyst formation; melanocytes visible within the stratum corneum, melanocytes scattered in the layers of the epidermis, black The level of uterine cells is expanded, true and epidermis boundaries are unclear. There is no obvious pigment cell nests in the dermis, see lymphocyte infiltration. Immunohistochemistry showed: HMB45 and S-100 protein (+), CK (+/-). Diagnosis: Seborrheic keratosis; melanoma in situ.