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对单用强心甙不能满意控制心室率的房颤患者,有人主张加服异搏定治疗,亦曾有过异搏定合用强心甙治疗折返型反复发作性室上性心动过速及合用地高辛治疗紊乱性心房律的临床报道,两药在过去是经常联合使用的。然而,异搏定与强心甙合用时,可出现电生理作用的相加及强心甙血药浓度的增高而诱发心律失常和心力衰竭。近年来,陆续有加服异搏定后发生地高辛中毒的临床病例报告。因此,两药联合使用时须特别谨慎。
A single cardiac glycoside can not be satisfied with the control of ventricular rate in patients with atrial fibrillation, it was advocated plus plus verapamil treatment, there have been verapamil combined with cardiac glycosides in the treatment of reentrant recurrent supraventricular tachycardia and Clinical reports of treatment of atrial fibrillation with digoxin, the two drugs in the past is often used in combination. However, verapamil combined with cardiac glycosides, there may be the addition of electrophysiological effects and increased plasma concentration of cardiac glycosides induced arrhythmia and heart failure. In recent years, one after another have been added plus verapamil clinical reports of digoxin poisoning. Therefore, the two drugs should be combined with special caution.