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目的探讨抗血管内皮生长因子(VEGF)药物联合糖皮质激素治疗糖尿病黄斑水肿(DME)的疗效。方法收集2014年1-12月唐山市华北理工大学附属医院住院治疗DME患者96例。分为单纯糖皮质激素治疗的对照组和抗VEGF药物联合糖皮质激素治疗的观察组,每组48例。观察治疗6个月后两组患者的视力变化情况。结果治疗后两组的视力均有所改善,差异有统计学意义(P<0.05)。观察组视力提高趋势明显,差异有统计学意义(P<0.05)。治疗后3个月疗效较治疗后1个月明显提高,治疗后3个月和6个月差异无统计学意义(P>0.05)。结论抗VEGF联合糖皮质激素更为有效,可能与抗VEGF促进血管再生相关。
Objective To investigate the therapeutic effect of anti-vascular endothelial growth factor (VEGF) and glucocorticoid on diabetic macular edema (DME). Methods Ninety-six patients with DME admitted to Affiliated Hospital of North China University of Technology in Tangshan from January to December 2014 were collected. Divided into simple glucocorticoid treatment control group and anti-VEGF drugs combined with glucocorticoid treatment observation group, 48 cases in each group. Visual acuity was observed in the two groups after 6 months of treatment. Results After treatment, the visual acuity of both groups improved, the difference was statistically significant (P <0.05). Visual acuity in the observation group increased significantly, the difference was statistically significant (P <0.05). Three months after treatment, the curative effect was significantly improved one month after treatment, but there was no significant difference between three months and six months after treatment (P> 0.05). Conclusion Anti-VEGF combined glucocorticoid is more effective and may be related to anti-VEGF to promote angiogenesis.