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目的:总结国内外关于叶绿酸(CHL)在肿瘤防治研究中的作用及其相关机制的进展。方法:应用PubMed及CNKI期刊全文数据库检索系统,以“CHL、肿瘤”等为关键词,检索2000-2010年的相关文献497篇。纳入标准:1)CHL的理化特点;2)CHL防治肿瘤的作用;3)CHL防治肿瘤的作用机制。根据纳入标准,符合分析的文献30篇。结果:CHL具有很强的抗诱变性和较好的抗肿瘤作用。其机制涉及抗氧化和清除自由基活性;抑制致癌物DNA加合物的形成;免疫调节的潜能等。结论:CHL在肿瘤防治中显示了良好的应用前景,值得进一步深入研究。
OBJECTIVE: To summarize the progress of studies on the role of chlorophyllin (CHL) in the prevention and treatment of cancer at home and abroad and its related mechanisms. Methods: Using PubMed and CNKI full-text database retrieval system, with “CHL, tumor” as the key word, 497 articles from 2000 to 2010 were retrieved. Inclusion criteria: 1) physical and chemical characteristics of CHL; 2) the role of CHL in the prevention and treatment of cancer; and 3) the mechanism of action of CHL in preventing and treating tumors. According to the inclusion criteria, 30 articles were analyzed. Results: CHL has strong anti-mutagenicity and better anti-tumor effect. Its mechanism involves antioxidant and scavenging free radical activity; inhibits the formation of carcinogen DNA adducts; the potential for immunomodulation and the like. Conclusion: CHL has shown a good application prospect in the prevention and treatment of cancer, which deserves further study.