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目的:探讨红花注射液预防化疗所致浅表静脉炎的疗效。方法:将恶性肿瘤患者随机分成治疗组和对照组,治疗组用红花注射液10ml+5%GS250ml在含刺激血管壁的化疗药物使用的前、后静脉滴注。对照组除不用红花注射液外,其余止吐、对症支持治疗与治疗组相同。结果:应用红花注射液后静脉炎发生率明显下降,治疗组发生率为26.4%(29/110),对照组发生率62.4%(68/109),两组比较有显著性差异(P<0.05)。治疗组无红花注射液相关严重毒性反应发生。结论:红花注射液是预防化疗药物所致浅表静脉炎的有效药物之一,毒副反应小,疗效好。
Objective: To investigate the effect of safflower injection in preventing superficial phlebitis caused by chemotherapy. Methods: The malignant tumor patients were randomly divided into treatment group and control group. The treatment group was given intravenous infusion of safflower injection 10ml + 5% GS250ml before and after chemotherapy drug containing vessel wall irritation. In addition to the control group without safflower injection, the rest antiemetic, symptomatic and supportive treatment and treatment of the same group. Results: The incidence of phlebitis was significantly decreased after application of safflower injection. The incidence of phlebitis in treatment group was 26.4% (29/110), while that in control group was 62.4% (68/109), with significant difference between the two groups (P < 0.05). Treatment group without safflower injection-related serious toxic reactions occurred. Conclusion: Safflower injection is one of the effective drugs to prevent superficial phlebitis caused by chemotherapy drugs. It has small toxicity and good curative effect.