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单羧酸转运体(monocarboxylate transporters,MCTs)属于溶质运载蛋白家族(solute carrier family,SLC)SLC16A亚家族成员.目前已发现该家族有14个成员;研究表明,MCTs具有偶联转运细胞新陈代谢中产生的单羧酸与质子的功能.MCTs在肿瘤组织中表达普遍增高,肿瘤细胞是以糖酵解代谢方式获取能量,该过程中产生的大量乳酸被MCTs运出胞外,以保护细胞因酸中毒诱发细胞凋亡;细胞外乳酸也能被肿瘤细胞摄取和利用.由于肿瘤组织的血管不发达,使肿瘤细胞内外的乳酸堆积,导致肿瘤细胞存活在缺氧和酸性微环境中,MCTs对此种环境中肿瘤细胞的存活与转移发挥重要作用.因此,研究肿瘤细胞和正常组织中MCTs的差异性表达及其机制,以及MCTs活性的调控机制,对于认识肿瘤细胞在缺氧和酸性微环境中存活与转移规律具有重要意义,并为肿瘤的治疗提供新的分子靶标.本文将对肿瘤中MCTs的功能研究的最新进展进行综述.同时,结合本室的研究提出一些见解.
Monocarboxylate transporters (MCTs) are members of the SLC16A subfamily of solute carrier families (SLCs), and it has been found that there are 14 members in this family. Studies have shown that MCTs are produced in the metabolism of coupled transporter cells Of the monocarboxylic acid and proton functions.MCTs generally expressed in the tumor tissue increased, the tumor cells are glycolytic metabolic access to energy, the process of large amounts of lactic acid produced by MCTs out of the extracellular, in order to protect cells from acidosis Induced apoptosis; extracellular lactate can also be taken up and utilized by tumor cells.As the blood vessels in tumor tissue are underdeveloped, lactic acid accumulates inside and outside of tumor cells, resulting in the survival of tumor cells in hypoxia and acidic microenvironment, Environment, tumor cells play an important role in the survival and metastasis.Therefore, the study of tumor cells and normal tissues of MCTs differential expression and its mechanism, as well as the regulation of MCTs activity mechanism for understanding tumor cells survive in hypoxia and acidic microenvironment And the transfer of the law is of great significance, and provide a new molecular target for the treatment of cancer.This paper will study the function of MCTs in the tumor Reviewed the latest developments. At the same time, research combined with the room to make some insight.