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采用银染技术，对84例上颌窦良、恶性病变标本进行了Ag－NORs研究。结果显示：上颌窦乳头状瘤及不典型增生的Ag－NORs计数明显高于单纯增生及正常粘膜，乳头状瘤癌变及鳞癌Ag－NORs计数又高于乳头状瘤及不典型增生（P＜0．05）。乳头状瘤与不典型增生间Ag－NORs计数无明显差别（二者都应视为癌前病变），乳头状瘤癌变与鳞癌间Ag－NORs计数也未见明显差别（P＞0．05）。鳞癌Ⅰ、Ⅱ级间以及Ⅰ、Ⅲ级间Ag－CORs计数差别显著（P＜0．05），Ⅱ、Ⅲ级间则无明显差别（P＞0．05）。结果表明，Ag-NORs计数在上颌窦良、恶性病变的鉴别及检测癌前病变上有一定价值，可作为上颌窦肿瘤的一个辅助诊断指标。
Ag-NORs were studied in 84 benign and malignant lesions of maxillary sinus using silver staining technique. The results showed that the counts of Ag-NORs in maxillary sinus papilloma and atypical hyperplasia were significantly higher than those in simple hyperplasia and normal mucosa. The counts of Ag-NORs in cancerous and squamous cell carcinomas were higher than those in papilloma and atypical hyperplasia (P < 0.05). There was no significant difference in Ag-NORs counts between papilloma and atypical hyperplasia (both should be regarded as precancerous lesion), and there was no significant difference in Ag-NORs count between carcinomatous papilloma and squamous cell carcinoma (P> 0.05 ). There were significant differences in Ag-CORs counts between grade Ⅰ and grade Ⅱ as well as between grade Ⅰ and grade Ⅲ (P <0.05). There was no significant difference between grade Ⅱ and grade Ⅲ (P> 0.05). The results show that the count of Ag-NORs in benign and malignant lesions of the maxillary sinus differential identification and detection of precancerous lesions have a value, can be used as a diagnosis of maxillary sinus tumor diagnostic indicators.