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目的CG及PU患者Hp感染后血清NO水平变化及其二者的相关性,以进一步研究Hp导致CG及PU的发病机制。方法所有受试者均经13C-尿素呼气实验和血清学检测Hp及其抗体。两者均为阳性者判定为Hp阳性,两者均为阴性者判定为阴性。血清NO测定:通过显色深浅测定其浓度的高低。结果本研究结果显示Hp阳性CG、PU患者血清NO含量显著高于正常对照组。Hp阴性PU患者血清NO含量显著低于正常组,而Hp阳性CG患者血清NO含量均显著高于Hp阴性CG患者。结论CG,PU的病理生理机制中可能有NO参与,并与Hp感染有关。
Objective To investigate the changes of serum NO levels after Hp infection in patients with CG and PU and their correlations so as to further study the pathogenesis of Hp-induced CG and PU. Methods All subjects were 13C-urea breath test and serological detection of Hp and its antibody. Hp was positive for both, and both were negative for negative. Determination of serum NO: determination of the level of its concentration by color depth. Results The results of this study showed that Hp-positive CG, PU serum NO levels were significantly higher than the normal control group. The serum NO level in patients with Hp-negative PU was significantly lower than that in the normal group, while the serum NO levels in Hp-positive CG patients were significantly higher than those in Hp-negative CG patients. Conclusions There may be NO involvement in the pathophysiological mechanism of CG and PU, which is related to Hp infection.